Albumin Is The Most Important Protein in Human Plasma

Albumin (albumin, also known as albumin) is the most important protein in human plasma, which maintains body nutrition and osmotic pressure. The concentration reached 38 ~ 48g / L, accounting for about 50% of the total plasma protein. The liver synthesizes about 12g-20g albumin every day. The mature albumin is a single polypeptide chain containing 585 amino acid residues, and the molecular shape is oval. [1] The concentration of globulin is 15 ~ 30g / L. Albumin / globulin (a/g) has important clinical significance. The normal value of a / G is 1.5 ~ 2.5:1. The increase of a / g may be the increase of albumin caused by malnutrition or the lack of immunoglobulin (antibody). The decrease of a / g may be due to the decrease of albumin: ① the decrease of synthetic ability, ② the increase of extravascular exudation, renal sclerosis, protein exudative gastrointestinal inflammation, liver cirrhosis, burns, malignant tumors, etc; Or because of the increase of globulin: (1) increased antibody caused by infectious diseases, and abnormal protein increased by bone marrow tumor. The decrease of serum albumin and a / G has important clinical significance in reflecting the degree of liver function in liver cirrhosis.